Description
Benefits of Selank:
Selank is primarily known for its dual anxiolytic (anti-anxiety) and nootropic (cognitive-enhancing) properties. In Russia and some other countries, it is an approved pharmaceutical and has been used clinically for:
- Anxiety Reduction: It effectively reduces symptoms of generalized anxiety disorder (GAD) and stress without the sedating side effects, dependence, or withdrawal problems associated with traditional anxiolytics like benzodiazepines.
- Cognitive Enhancement: It has been shown to improve memory, learning capacity, focus, and concentration, particularly in individuals with cognitive decline or under stress.
- Mood Improvement: By influencing neurotransmitter levels, it can help stabilize mood and alleviate symptoms of depression.
- Neuroprotection: It may help protect neurons from damage and promote neuroplasticity, potentially offering benefits for conditions like traumatic brain injuries or age-related cognitive issues.
- Immune System Support: As an analogue of tuftsin, an immune-modulating peptide, Selank can influence immune responses and has potential anti-inflammatory and antiviral properties.
Mechanism of Action
Selank works through multiple pathways in the central nervous system:
- GABAergic System Modulation: It acts as a positive allosteric modulator of GABAA receptors, similar to benzodiazepines, but without causing the same level of sedation or dependence. This action helps to calm the nervous system.
- Neurotransmitter Regulation: It modulates the levels and metabolism of key neurotransmitters, including serotonin, dopamine, and norepinephrine, which are involved in mood, motivation, and attention.
- BDNF Upregulation: It rapidly increases the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus, a protein vital for neuronal health, growth, and memory formation.
- Immune and Stress Response: It modulates the expression of cytokines like Interleukin-6 (IL-6) and affects the balance of T helper cells, influencing the body’s stress-immune axis and enhancing stress resilience.
Dosing protocol:
500mcg-1mg every evening, for 4-6 weeks.